3M™ Polisher ST

  • Unaffected by process fluid turbidity up to 40 NTU.
  • The 3M™ Polisher ST is a single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalised membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions.
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution.
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Hauteur totale (métrique)
Overall_Height_Metric
Largeur totale (métrique)
Overall_Width_Metric
Zone de filtration effective (métrique)
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 Hauteur totale (métrique), Largeur totale (métrique)  Zone de filtration effective (métrique)
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Caractéristiques
Débit (métrique)
1 Millilitre per Minute, 1020 Millilitre per Minute, 170 Millilitre per Minute, 25 Millilitre per Minute, 340 Millilitre per Minute, 4 Millilitre per Minute
Durée de vie du filtre
2 ans
Intégrité testée en usine
Capsule Leak Test
Marque
3M™
Matériau du filtre
Quaternary Ammonium Functional Polymer Grafted to a Polypropylene Nonwoven Guanidinium Functional Polyamide Membrane
Matériau du joint d'étanchéité
Fluorocarbone
Plage de pression (métrique)
0.34 bar Differential Pressure up to 1.4 bar Differential Pressure
Plage de températures (Celsius)
Up to 40 °C
Poids Net
1,1 kg, 1,2 kg, 1,8 kg, 10 g, 15,5 g, 72 g, 78 g
Secteurs
Sciences de la vie
Série du produit
Polisher ST
Taille d'admission/sortie
1,90 cm (3/4 po)
Température de fonctionnement maximum (Celsius)
40 °C
Température de stockage
32 °F - 86 °F
Type de filtre
Usage unique
Unités par boîte
1, 2, 4
Détails du produit
  • Unaffected by process fluid turbidity up to 40 NTU.
  • The 3M™ Polisher ST is a single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalised membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions.
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution.
  • Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins.

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane.

The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalised membrane downstream of the functionalised nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.

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